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Structure paper

TitleGIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.
Journal, issue, pagesGenes Dev., Vol. 31, Page 1147-1161, Year 2017
Publish dateMay 4, 2017 (structure data deposition date)
AuthorsPeter, D. / Weber, R. / Sandmeir, F. / Wohlbold, L. / Helms, S. / Bawankar, P. / Valkov, E. / Igreja, C. / Izaurralde, E.
External linksGenes Dev. / PubMed:28698298
MethodsX-ray diffraction
Resolution1.9 - 2.9 Å
Structure data

PDB-5nvk:
Crystal structure of the human 4EHP-GIGYF1 complex
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-5nvl:
Crystal structure of the human 4EHP-GIGYF2 complex
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-5nvm:
Crystal structure of the human 4EHP-GIGYF2 complex lacking the auxiliary sequences
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5nvn:
Crystal structure of the human 4EHP-4E-BP1 complex
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

ChemComp-FMT:
FORMIC ACID

Source
  • homo sapiens (human)
KeywordsTRANSLATION / translational regulation / cap-binding protein / 4EHP-binding protein / GRB10-interacting GYF protein 1 / GRB10-interacting GYF protein 2 / translation initiation / eIF4E-binding protein 1

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