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TitleChirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
Journal, issue, pagesJ. Am. Chem. Soc., Year 2017
Publish dateMar 2, 2017 (structure data deposition date)
AuthorsSchlegel, M.K. / Foster, D.J. / Kel'in, A.V. / Zlatev, I. / Bisbe, A. / Jayaraman, M. / Lackey, J.G. / Rajeev, K.G. / Charisse, K. / Harp, J. ...Schlegel, M.K. / Foster, D.J. / Kel'in, A.V. / Zlatev, I. / Bisbe, A. / Jayaraman, M. / Lackey, J.G. / Rajeev, K.G. / Charisse, K. / Harp, J. / Pallan, P.S. / Maier, M.A. / Egli, M. / Manoharan, M.
External linksJ. Am. Chem. Soc. / PubMed:28570818
MethodsX-ray diffraction
Resolution1.08001306231 - 1.2 Å
Structure data

PDB-5v1k:
Structure of R-GNA dodecamer
Method: X-RAY DIFFRACTION / Resolution: 1.18 Å

PDB-5v1l:
Structure of S-GNA dodecamer
Method: X-RAY DIFFRACTION / Resolution: 1.2 Å

PDB-5v2h:
RNA octamer containing glycol nucleic acid, SgnT
Method: X-RAY DIFFRACTION / Resolution: 1.08001306231 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SR:
STRONTIUM ION

ChemComp-SPM:
SPERMINE

ChemComp-NCO:
COBALT HEXAMMINE(III)

ChemComp-MG:
Unknown entry

Source
  • synthetic construct (others)
KeywordsRNA / Glycol Nucleic Acid / GNA / RGNA / RNA X-ray structure / Nuclease Stability / modified RNA

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