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Title | BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen. |
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Journal, issue, pages | J. Med. Chem., Vol. 60, Page 4805-4817, Year 2017 |
Publish date | Jun 8, 2016 (structure data deposition date) |
Authors | Ayoub, A.M. / Hawk, L.M.L. / Herzig, R.J. / Jiang, J. / Wisniewski, A.J. / Gee, C.T. / Zhao, P. / Zhu, J.Y. / Berndt, N. / Offei-Addo, N.K. ...Ayoub, A.M. / Hawk, L.M.L. / Herzig, R.J. / Jiang, J. / Wisniewski, A.J. / Gee, C.T. / Zhao, P. / Zhu, J.Y. / Berndt, N. / Offei-Addo, N.K. / Scott, T.G. / Qi, J. / Bradner, J.E. / Ward, T.R. / Schonbrunn, E. / Georg, G.I. / Pomerantz, W.C.K. |
External links | J. Med. Chem. / PubMed:28535045 |
Methods | X-ray diffraction |
Resolution | 1.5 Å |
Structure data | PDB-5kdh: |
Chemicals | ChemComp-6RX: ChemComp-EDO: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | TRANSCRIPTION/INHIBITOR / BROMODOMAIN / CAP / HUNK1 / MCAP / PROTEIN BINDING-INHIBITOR COMPLEX / MITOTIC CHROMOSOME ASSOCIATED PROTEIN / CELL CYCLE / INHIBITOR / TRANSCRIPTION-INHIBITOR COMPLEX |