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Structure paper

TitleA Tunable Brake for HECT Ubiquitin Ligases.
Journal, issue, pagesMol. Cell, Vol. 66, Page 345-357.e6, Year 2017
Publish dateOct 3, 2016 (structure data deposition date)
AuthorsChen, Z. / Jiang, H. / Xu, W. / Li, X. / Dempsey, D.R. / Zhang, X. / Devreotes, P. / Wolberger, C. / Amzel, L.M. / Gabelli, S.B. / Cole, P.A.
External linksMol. Cell / PubMed:28475870
MethodsX-ray diffraction
Resolution2.3 - 2.75 Å
Structure data

PDB-5tj7:
Structure of WWP2 WW2-2,3-linker-HECT aa 334-398 linked to 485-865
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-5tj8:
Structure of WWP2 WW2-2,3-linker-HECT (no WW2 observed)
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-5tjq:
Structure of WWP2 2,3-linker-HECT
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-SCN:
THIOCYANATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / WWP2 / HECT Domain / WW2 / WWP1 / ITCH / autoinhibition

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