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TitleDominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Journal, issue, pagesNature, Vol. 545, Page 243-247, Year 2017
Publish dateMar 10, 2017 (structure data deposition date)
AuthorsOoi, J.D. / Petersen, J. / Tan, Y.H. / Huynh, M. / Willett, Z.J. / Ramarathinam, S.H. / Eggenhuizen, P.J. / Loh, K.L. / Watson, K.A. / Gan, P.Y. ...Ooi, J.D. / Petersen, J. / Tan, Y.H. / Huynh, M. / Willett, Z.J. / Ramarathinam, S.H. / Eggenhuizen, P.J. / Loh, K.L. / Watson, K.A. / Gan, P.Y. / Alikhan, M.A. / Dudek, N.L. / Handel, A. / Hudson, B.G. / Fugger, L. / Power, D.A. / Holt, S.G. / Coates, P.T. / Gregersen, J.W. / Purcell, A.W. / Holdsworth, S.R. / La Gruta, N.L. / Reid, H.H. / Rossjohn, J. / Kitching, A.R.
External linksNature / PubMed:28467828
MethodsX-ray diffraction
Resolution2.1 - 3.405 Å
Structure data

PDB-5v4m:
Structure of HLA-DR15 with bound alpha3(135-145) peptide
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-5v4n:
Structure of HLA-DR1 with bound alpha3(135-145) peptide
Method: X-RAY DIFFRACTION / Resolution: 3.405 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / HLA-DR / immune complex / antigen presenation

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