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TitleSurrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling.
Journal, issue, pagesNature, Vol. 545, Page 234-237, Year 2017
Publish dateJan 30, 2017 (structure data deposition date)
AuthorsJanda, C.Y. / Dang, L.T. / You, C. / Chang, J. / de Lau, W. / Zhong, Z.A. / Yan, K.S. / Marecic, O. / Siepe, D. / Li, X. ...Janda, C.Y. / Dang, L.T. / You, C. / Chang, J. / de Lau, W. / Zhong, Z.A. / Yan, K.S. / Marecic, O. / Siepe, D. / Li, X. / Moody, J.D. / Williams, B.O. / Clevers, H. / Piehler, J. / Baker, D. / Kuo, C.J. / Garcia, K.C.
External linksNature / PubMed:28467818
MethodsX-ray diffraction
Resolution2.994 - 3.2 Å
Structure data

PDB-5un5:
Frizzled-8 complex with designed surrogate Wnt agonist, crystal form 1
Method: X-RAY DIFFRACTION / Resolution: 2.994 Å

PDB-5un6:
Frizzled-8 complex with designed surrogate Wnt agonist, A1 dataset
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsSIGNALING PROTEIN/De Novo Protein / SIGNALING PROTEIN / SIGNALING PROTEIN-De Novo Protein complex

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