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TitleA Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine beta-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?
Journal, issue, pagesOxid Med Cell Longev, Vol. 2017, Page 8940321-8940321, Year 2017
Publish dateDec 12, 2016 (structure data deposition date)
AuthorsVicente, J.B. / Colaco, H.G. / Malagrino, F. / Santo, P.E. / Gutierres, A. / Bandeiras, T.M. / Leandro, P. / Brito, J.A. / Giuffre, A.
External linksOxid Med Cell Longev / PubMed:28421128
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-5mms:
Human cystathionine beta-synthase (CBS) p.P49L delta409-551 variant
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLYASE / cystathionine beta-synthase / hydrogen sulfide / transsulfuration / classical homocystinuria

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