タイトル | Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress beta-lactam antibiotic resistance. |
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ジャーナル・号・ページ | Protein Sci., Vol. 26, Page 1161-1170, Year 2017 |
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掲載日 | 2017年2月15日 (構造データの登録日) |
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著者 | Vadlamani, G. / Stubbs, K.A. / Desire, J. / Bleriot, Y. / Vocadlo, D.J. / Mark, B.L. |
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リンク | Protein Sci. / PubMed:28370529 |
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手法 | X線回折 |
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解像度 | 2.15 - 2.2 Å |
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構造データ | PDB-5utp: Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to N-ethylbutyryl-PUGNAc 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-5utq: Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to PUGNAc 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-5utr: Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-butyryl-4,5,6-trihydroxyazepane 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å |
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化合物 | ChemComp-8M7: N-[(2Z,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-{[(phenylcarbamoyl)oxy]imino}tetrahydro-2H-pyran-3-yl]-2-ethylbutanamide
ChemComp-OAN: O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE / PUGNAc / 阻害剤*YM
ChemComp-8MP: N-[(3S,4R,5R,6S)-4,5,6-trihydroxyazepan-3-yl]butanamide / (3S,4R,5R,6S)-3-ブチリルアミノ-4,5,6-トリヒドロキシ-2,3,4,5,6,7-ヘキサヒドロ-1H(以下略)
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由来 | - burkholderia cenocepacia (バクテリア)
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / Glycoside hydrolase / family 3 / NagZ / HYDROLASE-HYDROLASE INHIBITOR complex / GH |
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