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Structure paper

TitleStructure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 114, Page E2106-E2115, Year 2017
Publish dateDec 27, 2016 (structure data deposition date)
AuthorsAbbas, Y.M. / Laudenbach, B.T. / Martinez-Montero, S. / Cencic, R. / Habjan, M. / Pichlmair, A. / Damha, M.J. / Pelletier, J. / Nagar, B.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:28251928
MethodsX-ray diffraction
Resolution1.58 - 1.69 Å
Structure data

PDB-5udi:
IFIT1 monomeric mutant (L457E/L464E) with m7Gppp-AAAA (syn and anti conformations of cap)
Method: X-RAY DIFFRACTION / Resolution: 1.58 Å

PDB-5udj:
IFIT1 monomeric mutant (L457E/L464E) with Gppp-AAAA
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

PDB-5udk:
IFIT1 monomeric mutant (L457E/L464E) with PPP-AAAA
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-5udl:
IFIT1 N216A monomeric mutant (L457E/L464E) with m7Gppp-AAAA (anti conformation of cap)
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
  • unidentified (others)
KeywordsRNA BINDING PROTEIN / mRNA cap / N7-Methylguanosine-triphosphate RNA / tetratricopeptide repeat / Guanosine-triphosphate RNA / Triphosphate RNA

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