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Structure paper

Title6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.
Journal, issue, pagesEur J Med Chem, Vol. 128, Page 168-179, Year 2017
Publish dateNov 7, 2016 (structure data deposition date)
AuthorsTang, J. / Kirby, K.A. / Huber, A.D. / Casey, M.C. / Ji, J. / Wilson, D.J. / Sarafianos, S.G. / Wang, Z.
External linksEur J Med Chem / PubMed:28182989
MethodsX-ray diffraction
Resolution2.705 Å
Structure data

PDB-5tuq:
Crystal Structure of a 6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione Inhibitor in Complex with HIV Reverse Transcriptase
Method: X-RAY DIFFRACTION / Resolution: 2.705 Å

Chemicals

ChemComp-J63:
1-[(benzyloxy)methyl]-6-(cyclohexylmethyl)-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus type 1 group m subtype b (isolate bh10)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / HIV-1 / REVERSE TRANSCRIPTASE / INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex

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