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-Structure paper
Title | Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 27, Page 1311-1315, Year 2017 |
Publish date | Sep 9, 2016 (structure data deposition date) |
Authors | Kiryanov, A. / Natala, S. / Jones, B. / McBride, C. / Feher, V. / Lam, B. / Liu, Y. / Honda, K. / Uchiyama, N. / Kawamoto, T. ...Kiryanov, A. / Natala, S. / Jones, B. / McBride, C. / Feher, V. / Lam, B. / Liu, Y. / Honda, K. / Uchiyama, N. / Kawamoto, T. / Hikichi, Y. / Zhang, L. / Hosfield, D. / Skene, R. / Zou, H. / Stafford, J. / Cao, X. / Ichikawa, T. |
External links | Bioorg. Med. Chem. Lett. / PubMed:28169164 |
Methods | X-ray diffraction |
Resolution | 2.5 - 2.6 Å |
Structure data | PDB-5ta6: PDB-5ta8: |
Chemicals | ChemComp-79D: ChemComp-ZN: ChemComp-HOH: ChemComp-79C: |
Source |
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Keywords | Transferase/Transferase Inhibitor / PLK1 Inhibitor / Kinase / Structure-based drug design / Antitumor activity / Transferase-Transferase Inhibitor complex |