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TitleMolecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex.
Journal, issue, pagesStructure, Vol. 25, Issue 3, Page 434-445, Year 2017
Publish dateMar 7, 2017
AuthorsPaula Upla / Seung Joong Kim / Parthasarathy Sampathkumar / Kaushik Dutta / Sean M Cahill / Ilan E Chemmama / Rosemary Williams / Jeffrey B Bonanno / William J Rice / David L Stokes / David Cowburn / Steven C Almo / Andrej Sali / Michael P Rout / Javier Fernandez-Martinez /
PubMed AbstractThe membrane ring that equatorially circumscribes the nuclear pore complex (NPC) in the perinuclear lumen of the nuclear envelope is composed largely of Pom152 in yeast and its ortholog Nup210 (or ...The membrane ring that equatorially circumscribes the nuclear pore complex (NPC) in the perinuclear lumen of the nuclear envelope is composed largely of Pom152 in yeast and its ortholog Nup210 (or Gp210) in vertebrates. Here, we have used a combination of negative-stain electron microscopy, nuclear magnetic resonance, and small-angle X-ray scattering methods to determine an integrative structure of the ∼120 kDa luminal domain of Pom152. Our structural analysis reveals that the luminal domain is formed by a flexible string-of-pearls arrangement of nine repetitive cadherin-like Ig-like domains, indicating an evolutionary connection between NPCs and the cell adhesion machinery. The 16 copies of Pom152 known to be present in the yeast NPC are long enough to form the observed membrane ring, suggesting how interactions between Pom152 molecules help establish and maintain the NPC architecture.
External linksStructure / PubMed:28162953 / PubMed Central
MethodsEM (single particle) / NMR (solution)
Resolution25.0 Å
Structure data

EMDB-8543:
3D negative stain EM structure of Pom152, the major component of the membrane ring of the nuclear pore complex
Method: EM (single particle) / Resolution: 25.0 Å

PDB-5tvz:
Solution NMR structure of Saccharomyces cerevisiae Pom152 Ig-like repeat, residues 718-820
Method: SOLUTION NMR

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsTRANSPORT PROTEIN / Nuclear Pore Complex / Ig-like fold / nuclear envelope membrane / cadherin like fold

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