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TitleStructure of the 70S ribosome from human pathogen Staphylococcus aureus.
Journal, issue, pagesNucleic Acids Res, Vol. 44, Issue 21, Page 10491-10504, Year 2016
Publish dateDec 1, 2016
AuthorsIskander Khusainov / Quentin Vicens / Anthony Bochler / François Grosse / Alexander Myasnikov / Jean-François Ménétret / Johana Chicher / Stefano Marzi / Pascale Romby / Gulnara Yusupova / Marat Yusupov / Yaser Hashem /
PubMed AbstractComparative structural studies of ribosomes from various organisms keep offering exciting insights on how species-specific or environment-related structural features of ribosomes may impact ...Comparative structural studies of ribosomes from various organisms keep offering exciting insights on how species-specific or environment-related structural features of ribosomes may impact translation specificity and its regulation. Although the importance of such features may be less obvious within more closely related organisms, their existence could account for vital yet species-specific mechanisms of translation regulation that would involve stalling, cell survival and antibiotic resistance. Here, we present the first full 70S ribosome structure from Staphylococcus aureus, a Gram-positive pathogenic bacterium, solved by cryo-electron microscopy. Comparative analysis with other known bacterial ribosomes pinpoints several unique features specific to S. aureus around a conserved core, at both the protein and the RNA levels. Our work provides the structural basis for the many studies aiming at understanding translation regulation in S. aureus and for designing drugs against this often multi-resistant pathogen.
External linksNucleic Acids Res / PubMed:27906650 / PubMed Central
MethodsEM (single particle)
Resolution3.8 Å
Structure data

4050

5li0

EMDB-4050, PDB-5li0:
70S ribosome from Staphylococcus aureus
Method: EM (single particle) / Resolution: 3.8 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-O:
OXYGEN ATOM / Oxygen

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER / Water

Source
  • staphylococcus aureus (strain nctc 8325) (bacteria)
KeywordsRIBOSOME / pathogenic ribosome / bL31 B-type

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