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Structure paper

TitleStructure of a PKA RI alpha Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation.
Journal, issue, pagesJ. Mol. Biol., Vol. 428, Page 4890-4904, Year 2016
Publish dateMay 5, 2016 (structure data deposition date)
AuthorsBruystens, J.G. / Wu, J. / Fortezzo, A. / Del Rio, J. / Nielsen, C. / Blumenthal, D.K. / Rock, R. / Stefan, E. / Taylor, S.S.
External linksJ. Mol. Biol. / PubMed:27825928
MethodsX-ray diffraction
Resolution3.56 Å
Structure data

PDB-5jr7:
Crystal structure of an ACRDYS heterodimer [RIa(92-365):C] of PKA
Method: X-RAY DIFFRACTION / Resolution: 3.56 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

Source
  • mus musculus (house mouse)
  • bos taurus (domestic cattle)
KeywordsTransferase/cAMP binding Protein / PKA signaling / RIa subunit / disease mutations / dysfunctional ACRDYS mutant / Transferase-cAMP binding Protein complex

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