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Structure paper

TitleDefining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor.
Journal, issue, pagesStructure, Vol. 24, Page 2067-2079, Year 2016
Publish dateJul 14, 2016 (structure data deposition date)
AuthorsBrosey, C.A. / Ho, C. / Long, W.Z. / Singh, S. / Burnett, K. / Hura, G.L. / Nix, J.C. / Bowman, G.R. / Ellenberger, T. / Tainer, J.A.
External linksStructure / PubMed:27818101
MethodsX-ray diffraction
Resolution1.995 - 2.273 Å
Structure data

PDB-5kvh:
Crystal structure of human apoptosis-inducing factor with W196A mutation
Method: X-RAY DIFFRACTION / Resolution: 2.273 Å

PDB-5kvi:
Crystal structure of monomeric human apoptosis-inducing factor with E413A/R422A/R430A mutations
Method: X-RAY DIFFRACTION / Resolution: 1.995 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Flavoprotein / Mitochondria / Cell death / Mitochondria Cell death

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