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TitleThe facial triad in the alpha-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation.
Journal, issue, pagesJ. Inorg. Biochem., Vol. 166, Page 26-33, Year 2016
Publish dateMay 12, 2016 (structure data deposition date)
AuthorsHangasky, J.A. / Taabazuing, C.Y. / Martin, C.B. / Eron, S.J. / Knapp, M.J.
External linksJ. Inorg. Biochem. / PubMed:27815979
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-5jwp:
Crystal structure of human FIH D201E variant in complex with Zn, alpha-ketoglutarate, and HIF1 alpha peptide.
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-AKG:
2-OXOGLUTARIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-ZN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Hypoxia sensing / Factor Inhibiting HIF / alpha-ketoglutarate dependent oxygenase / Hypoxia inducible factor / hydroxylase

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