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TitleAvilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 113, Page E6796-E6805, Year 2016
Publish dateMay 11, 2016 (structure data deposition date)
AuthorsKrupkin, M. / Wekselman, I. / Matzov, D. / Eyal, Z. / Diskin Posner, Y. / Rozenberg, H. / Zimmerman, E. / Bashan, A. / Yonath, A.
External linksProc. Natl. Acad. Sci. USA / PubMed:27791159
MethodsX-ray diffraction
Resolution3.428 - 3.58 Å
Structure data

PDB-5jvg:
The large ribosomal subunit from Deinococcus radiodurans in complex with avilamycin
Method: X-RAY DIFFRACTION / Resolution: 3.428 Å

PDB-5jvh:
The crystal structure large ribosomal subunit (50S) of Deinococcus radiodurans in complex with evernimicin
Method: X-RAY DIFFRACTION / Resolution: 3.58 Å

Chemicals

ChemComp-6NO:
Avilamycin

ChemComp-MG:
Unknown entry

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-SPD:
SPERMIDINE

ChemComp-6O1:
Evernimicin

Source
  • deinococcus radiodurans r1 (radioresistant)
  • deinococcus radiodurans (strain atcc 13939 / dsm 20539 / jcm 16871 / lmg 4051 / nbrc 15346 / ncimb 9279 / r1 / vkm b-1422) (radioresistant)
  • deinococcus radiodurans (radioresistant)
KeywordsRIBOSOME / Deinococcus radiodurans / avilamycin / degradable antibiotics / large ribosomal subunit / resistance / Antibiotics

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