EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction.
ジャーナル・号・ページ	J. Med. Chem., Vol. 59, Page 10147-10162, Year 2016
掲載日	2016年6月15日 (構造データの登録日)
著者	Gollner, A. / Rudolph, D. / Arnhof, H. / Bauer, M. / Blake, S.M. / Boehmelt, G. / Cockroft, X.L. / Dahmann, G. / Ettmayer, P. / Gerstberger, T. ...Gollner, A. / Rudolph, D. / Arnhof, H. / Bauer, M. / Blake, S.M. / Boehmelt, G. / Cockroft, X.L. / Dahmann, G. / Ettmayer, P. / Gerstberger, T. / Karolyi-Oezguer, J. / Kessler, D. / Kofink, C. / Ramharter, J. / Rinnenthal, J. / Savchenko, A. / Schnitzer, R. / Weinstabl, H. / Weyer-Czernilofsky, U. / Wunberg, T. / McConnell, D.B.
リンク	J. Med. Chem. / PubMed:27775892
手法	X線回折
解像度	1.64 - 2.71 Å
構造データ	PDB-5lav: Novel Spiro[3H-indole-3,2 -pyrrolidin]-2(1H)-one Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) in complex with compound 6b 手法: X-RAY DIFFRACTION / 解像度: 1.73 Å PDB-5law: Novel Spiro[3H-indole-3,2 -pyrrolidin]-2(1H)-one Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND 14 手法: X-RAY DIFFRACTION / 解像度: 1.64 Å PDB-5lay: Discovery of New Natural-product-inspired Spiro-oxindole Compounds as Orally Active Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND 6g 手法: X-RAY DIFFRACTION / 解像度: 2.71 Å PDB-5laz: Novel Spiro[3H-indole-3,2 -pyrrolidin]-2(1H)-one Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND BI-0252 手法: X-RAY DIFFRACTION / 解像度: 1.66 Å
化合物	ChemComp-6SK: (3~{S},3'~{S},4'~{S})-4'-azanyl-6-chloranyl-3'-(3-chlorophenyl)-1'-(2,2-dimethylpropyl)spiro[1~{H}-indole-3,2'-pyrrolidine]-2-one ChemComp-SO4: SULFATE ION / 硫酸ジアニオン / 硫酸塩 ChemComp-HOH: WATER / 水 ChemComp-6SJ: 2-[(3~{S},3'~{a}~{S},6'~{S},6'~{a}~{S})-6-chloranyl-6'-(3-chlorophenyl)-4'-(cyclopropylmethyl)-2-oxidanylidene-spiro[1~{H}-indole-3,5'-3,3~{a},6,6~{a}-tetrahydro-2~{H}-pyrrolo[3,2-b]pyrrole]-1'-yl]ethanoic acid ChemComp-GOL: GLYCEROL / グリセロ-ル / グリセリン ChemComp-6SS: (3~{S},3'~{S},4'~{S},5'~{S})-4'-azanyl-6-chloranyl-3'-(3-chloranyl-2-fluoranyl-phenyl)-1'-[(3-ethoxyphenyl)methyl]-5'-methyl-spiro[1~{H}-indole-3,2'-pyrrolidine]-2-one ChemComp-6ST: 4-[(2~{R},3~{a}~{S},5~{S},6~{S},6~{a}~{S})-6'-chloranyl-6-(3-chloranyl-2-fluoranyl-phenyl)-4-(cyclopropylmethyl)-2'-oxidanylidene-spiro[1,2,3,3~{a},6,6~{a}-hexahydropyrrolo[3,2-b]pyrrole-5,3'-1~{H}-indole]-2-yl]benzoic acid ChemComp-ZN: Unknown entry
由来	homo sapiens (ヒト)
キーワード	LIGASE (リガーゼ) / VIENNA / PPI / MDM2 (Mdm2) / HDM2 / BI