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TitleRobotic Qm/Mm-Driven Maturation of Antibody Combining Sites.
Journal, issue, pagesSci. Adv., Vol. 2, Page 01695-, Year 2016
Publish dateAug 21, 2015 (structure data deposition date)
AuthorsSmirnov, I.V. / Golovin, A.V. / Chatziefthimiou, S.D. / Stepanova, A.V. / Peng, Y. / Zolotareva, O.I. / Belogurov, A.A. / Kurkova, I.N. / Ponomarenko, N.A. / Wilmanns, M. ...Smirnov, I.V. / Golovin, A.V. / Chatziefthimiou, S.D. / Stepanova, A.V. / Peng, Y. / Zolotareva, O.I. / Belogurov, A.A. / Kurkova, I.N. / Ponomarenko, N.A. / Wilmanns, M. / Blackburn, G.M. / Gabibov, A.G. / Lerner, R.A.
External linksSci. Adv. / PubMed:27774510
MethodsX-ray diffraction
Resolution1.55 - 2.13 Å
Structure data

PDB-5ado:
Crystal structure of the paraoxon-modified A.17 antibody FAB fragment - Light chain S35R mutant
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-5adp:
Crystal structure of the A.17 antibody FAB fragment - Light chain S35R mutant
Method: X-RAY DIFFRACTION / Resolution: 2.13 Å

Chemicals

ChemComp-DEP:
DIETHYL PHOSPHONATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / ENZYME REPROGRAMMING / ANTIBODIES / IG SUPERFAMILY / IN SILICO ANTIBODY MATURATION

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