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Structure paper

TitleOmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
Journal, issue, pagesOncogene, Vol. 36, Page 1911-1924, Year 2017
Publish dateFeb 13, 2016 (structure data deposition date)
AuthorsJung, L.A. / Gebhardt, A. / Koelmel, W. / Ade, C.P. / Walz, S. / Kuper, J. / von Eyss, B. / Letschert, S. / Redel, C. / d'Artista, L. ...Jung, L.A. / Gebhardt, A. / Koelmel, W. / Ade, C.P. / Walz, S. / Kuper, J. / von Eyss, B. / Letschert, S. / Redel, C. / d'Artista, L. / Biankin, A. / Zender, L. / Sauer, M. / Wolf, E. / Evan, G. / Kisker, C. / Eilers, M.
External linksOncogene / PubMed:27748763
MethodsX-ray diffraction
Resolution1.95 - 2.701 Å
Structure data

PDB-5i4z:
Structure of apo OmoMYC
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-5i50:
Structure of OmoMYC bound to double-stranded DNA
Method: X-RAY DIFFRACTION / Resolution: 2.701 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSCRIPTION / leucine zipper / transcription factor / tumor suppressor / E-box

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