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Structure paper

TitleRNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targeting.
Journal, issue, pagesNucleic Acids Res., Vol. 44, Page 10862-10878, Year 2016
Publish dateFeb 2, 2016 (structure data deposition date)
AuthorsRajappa-Titu, L. / Suematsu, T. / Munoz-Tello, P. / Long, M. / Demir, O. / Cheng, K.J. / Stagno, J.R. / Luecke, H. / Amaro, R.E. / Aphasizheva, I. ...Rajappa-Titu, L. / Suematsu, T. / Munoz-Tello, P. / Long, M. / Demir, O. / Cheng, K.J. / Stagno, J.R. / Luecke, H. / Amaro, R.E. / Aphasizheva, I. / Aphasizhev, R. / Thore, S.
External linksNucleic Acids Res. / PubMed:27744351
MethodsX-ray diffraction
Resolution1.6 - 2.75 Å
Structure data

PDB-5hzd:
RNA Editing TUTase 1 from Trypanosoma brucei
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-5i49:
RNA Editing TUTase 1 from Trypanosoma brucei in complex with UTP analog UMPNPP
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-5ido:
RNA Editing TUTase 1 from Trypanosoma brucei in complex with UTP
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-5kal:
Terminal uridylyl transferase 4 from Trypanosoma brucei with bound UTP and UpU
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-2KH:
5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine

ChemComp-MG:
Unknown entry

ChemComp-UTP:
URIDINE 5'-TRIPHOSPHATE / UTP*YM

Source
  • trypanosoma brucei (eukaryote)
KeywordsTRANSFERASE / RNA Editing TUTase1 / Trypanosoma brucei / Transferase/RNA / trypanosoma / RNA editing / TUTase / Transferase-RNA complex

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