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Structure paper

TitleGerminal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension.
Journal, issue, pagesProtein Sci., Vol. 26, Page 152-162, Year 2017
Publish dateApr 3, 2016 (structure data deposition date)
AuthorsMarcotte, D. / Rushe, M. / M Arduini, R. / Lukacs, C. / Atkins, K. / Sun, X. / Little, K. / Cullivan, M. / Paramasivam, M. / Patterson, T.A. ...Marcotte, D. / Rushe, M. / M Arduini, R. / Lukacs, C. / Atkins, K. / Sun, X. / Little, K. / Cullivan, M. / Paramasivam, M. / Patterson, T.A. / Hesson, T. / D McKee, T. / May-Dracka, T.L. / Xin, Z. / Bertolotti-Ciarlet, A. / Bhisetti, G.R. / Lyssikatos, J.P. / Silvian, L.F.
External linksProtein Sci. / PubMed:27727493
MethodsX-ray diffraction
Resolution2.85 Å
Structure data

PDB-5j5t:
GLK co-crystal structure with aminopyrrolopyrimidine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-6G2:
5-[2-(piperidin-4-yl)-1,3-thiazol-5-yl]-3-[(pyridin-4-yl)methoxy]pyridin-2-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / Protein kinsae / Transferase-Transferase Inhibitor complex

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