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Structure paper

TitleThe structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
Journal, issue, pagesSci Rep, Vol. 6, Page 34303-34303, Year 2016
Publish dateApr 29, 2016 (structure data deposition date)
AuthorsDahms, S.O. / Creemers, J.W. / Schaub, Y. / Bourenkov, G.P. / Zogg, T. / Brandstetter, H. / Than, M.E.
External linksSci Rep / PubMed:27670069
MethodsX-ray diffraction
Resolution1.998 - 2.27 Å
Structure data

PDB-5jmo:
X-ray structure of furin in complex with the inhibitory antibody Nb14
Method: X-RAY DIFFRACTION / Resolution: 1.998 Å

PDB-5jmr:
X-ray structure of the furin inhibitory antibody Nb14
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CA:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
  • camelus dromedarius (Arabian camel)
  • synthetic construct (others)
KeywordsHydrolase/Antibody / protease / camelid / antibody / complex / Hydrolase-Antibody complex / furin / IMMUNE SYSTEM / inhibitor

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