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TitleProximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells
Journal, issue, pagesAcs Cent. Sci., Vol. 2, Page 506-516, Year 2016
Publish dateAug 2, 2016 (structure data deposition date)
AuthorsLee, S.Y. / Lee, H. / Lee, H.K. / Lee, S.W. / Ha, S.C. / Kwon, T. / Seo, J.K. / Lee, C. / Rhee, H.W.
External linksAcs Cent. Sci. / PubMed:27610411
MethodsX-ray diffraction
Resolution1.67 Å
Structure data

PDB-5gpg:
Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB domain of human mTOR
Method: X-RAY DIFFRACTION / Resolution: 1.67 Å

Chemicals

ChemComp-RAP:
RAPAMYCIN IMMUNOSUPPRESSANT DRUG / immunosuppressant, antibiotic*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsISOMERASE/TRANSFERASE / complex / kinase / ISOMERASE-TRANSFERASE complex

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