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TitlePhage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish.
Journal, issue, pagesProtein Sci., Vol. 25, Page 2076-2088, Year 2016
Publish dateApr 19, 2016 (structure data deposition date)
AuthorsTucker, M.B. / MacKenzie, S.H. / Maciag, J.J. / Dirscherl Ackerman, H. / Swartz, P. / Yoder, J.A. / Hamilton, P.T. / Clay Clark, A.
External linksProtein Sci. / PubMed:27577093
MethodsX-ray diffraction
Resolution2.28 Å
Structure data

PDB-5jft:
Zebra Fish Caspase-3
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

Chemicals

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-MRD:
(4R)-2-METHYLPENTANE-2,4-DIOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • danio rerio (zebrafish)
  • unidentified 'cnm-group' bacterium hxn600 (bacteria)
KeywordsHydrolase/Hydrolase Inhibitor / phage display substrate library / substrate recognition / Danio rerio / apoptosis / HYDROLASE / Hydrolase-Hydrolase Inhibitor complex

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