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Structure paper

TitleStructural basis for early-onset neurological disorders caused by mutations in human selenocysteine synthase.
Journal, issue, pagesSci Rep, Vol. 6, Page 32563-32563, Year 2016
Publish dateApr 17, 2015 (structure data deposition date)
AuthorsPuppala, A.K. / French, R.L. / Matthies, D. / Baxa, U. / Subramaniam, S. / Simonovic, M.
External linksSci Rep / PubMed:27576344
MethodsX-ray diffraction
Resolution2.26 - 2.703 Å
Structure data

PDB-4zdl:
The crystal structure of the T325S mutant of the human holo SepSecS
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

PDB-4zdo:
The crystal structure of T325S mutant of human SepSecS in complex with selenocysteine tRNA (tRNASec)
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

PDB-4zdp:
The crystal structure of Y334C mutant of human SepSecS in complex with selenocysteine tRNA (tRNASec)
Method: X-RAY DIFFRACTION / Resolution: 2.703 Å

Chemicals

ChemComp-PLR:
(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE

ChemComp-FLC:
CITRATE ANION

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / selenocysteine / pyridoxal phosphate / mutation / Transferase/RNA / tRNA / Transferase-RNA complex

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