タイトル | Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening. |
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ジャーナル・号・ページ | Structure, Vol. 24, Page 1629-1642, Year 2016 |
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掲載日 | 2016年6月14日 (構造データの登録日) |
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著者 | Ng, L.C. / Putrenko, I. / Baronas, V. / Van Petegem, F. / Accili, E.A. |
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リンク | Structure / PubMed:27568927 |
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手法 | X線回折 |
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解像度 | 1.77 - 2.241 Å |
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構造データ | PDB-5khg: HCN2 CNBD in complex with cytidine-3', 5'-cyclic monophosphate (cCMP) 手法: X-RAY DIFFRACTION / 解像度: 2.241 Å PDB-5khh: HCN2 CNBD in complex with inosine-3', 5'-cyclic monophosphate (cIMP) 手法: X-RAY DIFFRACTION / 解像度: 1.77 Å PDB-5khi: HCN2 CNBD in complex with purine riboside-3', 5'-cyclic monophosphate (cPuMP) 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-5khj: HCN2 CNBD in complex with uridine-3', 5'-cyclic monophosphate (cUMP) 手法: X-RAY DIFFRACTION / 解像度: 2.01 Å PDB-5khk: HCN2 CNBD in complex with 2-aminopurine riboside-3', 5'-cyclic monophosphate (2-NH2-cPuMP) 手法: X-RAY DIFFRACTION / 解像度: 2.07 Å |
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化合物 | ChemComp-CC7: 4-amino-1-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidin-2(1H)-one / cCMP
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由来 | ![](img/tx_mammal.gif) mus musculus (ハツカネズミ)
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キーワード | TRANSPORT PROTEIN / protein-ligand complex / cycilc nucleotide binding domain / ion transport |
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