タイトル | Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase. |
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ジャーナル・号・ページ | Biochemistry, Vol. 55, Page 5180-5190, Year 2016 |
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掲載日 | 2016年1月18日 (構造データの登録日) |
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著者 | G Ricci, C. / Liu, Y.L. / Zhang, Y. / Wang, Y. / Zhu, W. / Oldfield, E. / McCammon, J.A. |
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リンク | Biochemistry / PubMed:27564465 |
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手法 | X線回折 |
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解像度 | 2.12 - 2.7 Å |
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構造データ | PDB-5hn7: Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1158 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-5hn8: Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1182 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-5hn9: Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1186 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å PDB-5hna: Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1251 手法: X-RAY DIFFRACTION / 解像度: 2.693 Å |
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化合物 | ChemComp-04M: 5-(morpholin-4-ylsulfonyl)-2-{[3-(octyloxy)benzyl]oxy}benzoic acid
ChemComp-HXK: 2-{[3-hydroxy-5-(octyloxy)benzyl]sulfanyl}benzoic acid
ChemComp-04W: 2-{[3-(decyloxy)benzyl]oxy}-5-nitrobenzoic acid
ChemComp-63D: 4-chloro-2-{[3-(decyloxy)-5-hydroxybenzyl]oxy}-5-sulfamoylbenzoic acid
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由来 | ![](img/tx_eukaryote.gif) plasmodium vivax (マラリア 病原虫)
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX / ALL HELICES |
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