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TitleTargeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
Journal, issue, pagesJ. Biol. Chem., Vol. 291, Page 22357-22372, Year 2016
Publish dateAug 9, 2016 (structure data deposition date)
AuthorsAlicea-Velazquez, N.L. / Shinsky, S.A. / Loh, D.M. / Lee, J.H. / Skalnik, D.G. / Cosgrove, M.S.
External linksJ. Biol. Chem. / PubMed:27563068
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-5sxm:
WDR5 in complex with MLL Win motif peptidomimetic
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / beta propeller / WD40 repeat / transcription regulator / scaffold

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