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-Structure paper
Title | An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. |
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Journal, issue, pages | J. Exp. Med., Vol. 213, Page 1741-1757, Year 2016 |
Publish date | Jul 28, 2016 (structure data deposition date) |
Authors | Atapattu, L. / Saha, N. / Chheang, C. / Eissman, M.F. / Xu, K. / Vail, M.E. / Hii, L. / Llerena, C. / Liu, Z. / Horvay, K. ...Atapattu, L. / Saha, N. / Chheang, C. / Eissman, M.F. / Xu, K. / Vail, M.E. / Hii, L. / Llerena, C. / Liu, Z. / Horvay, K. / Abud, H.E. / Kusebauch, U. / Moritz, R.L. / Ding, B.S. / Cao, Z. / Rafii, S. / Ernst, M. / Scott, A.M. / Nikolov, D.B. / Lackmann, M. / Janes, P.W. |
External links | J. Exp. Med. / PubMed:27503072 |
Methods | X-ray diffraction |
Resolution | 2.759 Å |
Structure data | PDB-5l0q: |
Chemicals | ChemComp-NAG: ChemComp-SO4: ChemComp-MG: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/IMMUNE SYSTEM / ADAM protease / mAb / 8C7 / Notch signaling / therapeutic antibody / cancer stem cell / drug resistance / HYDROLASE-IMMUNE SYSTEM complex |