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Structure paper

TitleA Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor.
Journal, issue, pagesJ. Biol. Chem., Vol. 291, Page 19674-19686, Year 2016
Publish dateJun 8, 2016 (structure data deposition date)
AuthorsKaya, A.I. / Lokits, A.D. / Gilbert, J.A. / Iverson, T.M. / Meiler, J. / Hamm, H.E.
External linksJ. Biol. Chem. / PubMed:27462082
MethodsX-ray diffraction
Resolution1.9 - 2.665 Å
Structure data

PDB-5kdl:
Crystal structure of the 4 alanine insertion variant of the Gi alpha1 subunit bound to GTPgammaS
Method: X-RAY DIFFRACTION / Resolution: 2.665 Å

PDB-5kdo:
Heterotrimeric complex of the 4 alanine insertion variant of the Gi alpha1 subunit and the Gbeta1-Ggamma1
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GSP:
5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE

ChemComp-HOH:
WATER

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

Source
  • rattus norvegicus (Norway rat)
  • bos taurus (domestic cattle)
KeywordsSIGNALING PROTEIN / Heterotrimeric G protein G protein Coupled Receptors G protein activation G protein structure GDP release

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