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TitleStructure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes.
Journal, issue, pagesCell, Vol. 166, Page 596-608, Year 2016
Publish dateMay 11, 2016 (structure data deposition date)
AuthorsKallewaard, N.L. / Corti, D. / Collins, P.J. / Neu, U. / McAuliffe, J.M. / Benjamin, E. / Wachter-Rosati, L. / Palmer-Hill, F.J. / Yuan, A.Q. / Walker, P.A. ...Kallewaard, N.L. / Corti, D. / Collins, P.J. / Neu, U. / McAuliffe, J.M. / Benjamin, E. / Wachter-Rosati, L. / Palmer-Hill, F.J. / Yuan, A.Q. / Walker, P.A. / Vorlaender, M.K. / Bianchi, S. / Guarino, B. / De Marco, A. / Vanzetta, F. / Agatic, G. / Foglierini, M. / Pinna, D. / Fernandez-Rodriguez, B. / Fruehwirth, A. / Silacci, C. / Ogrodowicz, R.W. / Martin, S.R. / Sallusto, F. / Suzich, J.A. / Lanzavecchia, A. / Zhu, Q. / Gamblin, S.J. / Skehel, J.J.
External linksCell / PubMed:27453466
MethodsX-ray diffraction
Resolution1.9 - 3.75 Å
Structure data

PDB-5jw3:
Structure of MEDI8852 Fab Fragment in Complex with H7 HA
Method: X-RAY DIFFRACTION / Resolution: 3.75 Å

PDB-5jw4:
Structure of MEDI8852 Fab Fragment in Complex with H5 HA
Method: X-RAY DIFFRACTION / Resolution: 3.7 Å

PDB-5jw5:
Structure of MEDI8852 Fab Fragment
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • influenza a virus (a/turkey/italy/214845/2002(h7n3))
  • influenza a virus
KeywordsIMMUNE SYSTEM / Antibody Influenza Broadly Neutralizing / Antibody Influenza

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