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Structure paper

TitleMolecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM.
Journal, issue, pagesNucleic Acids Res., Vol. 44, Page 10423-10436, Year 2016
Publish dateOct 14, 2015 (structure data deposition date)
AuthorsVarshney, D. / Petit, A.P. / Bueren-Calabuig, J.A. / Jansen, C. / Fletcher, D.A. / Peggie, M. / Weidlich, S. / Scullion, P. / Pisliakov, A.V. / Cowling, V.H.
External linksNucleic Acids Res. / PubMed:27422871
MethodsX-ray diffraction
Resolution2.283 - 3.47 Å
Structure data

PDB-5e8j:
Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with RAM
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-5e9j:
Crystal structure of the mRNA cap guanine-N7 methyltransferase - modular lobe (416-456) deletion
Method: X-RAY DIFFRACTION / Resolution: 3.47 Å

PDB-5e9w:
Crystal structure of mRNA cap guanine-N7 methyltransferase obtained by limited proteolysis
Method: X-RAY DIFFRACTION / Resolution: 2.283 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSLATION / mRNA capping / mRNA processing / TRANSFERASE / RNA processing

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