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-Structure paper
Title | RNA polymerase I-Rrn3 complex at 4.8 Å resolution. |
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Journal, issue, pages | Nat Commun, Vol. 7, Page 12129, Year 2016 |
Publish date | Jul 15, 2016 |
Authors | Christoph Engel / Jürgen Plitzko / Patrick Cramer / |
PubMed Abstract | Transcription of ribosomal DNA by RNA polymerase I (Pol I) requires the initiation factor Rrn3. Here we report the cryo-EM structure of the Pol I-Rrn3 complex at 4.8 Å resolution. The structure ...Transcription of ribosomal DNA by RNA polymerase I (Pol I) requires the initiation factor Rrn3. Here we report the cryo-EM structure of the Pol I-Rrn3 complex at 4.8 Å resolution. The structure reveals how Rrn3 binding converts an inactive Pol I dimer into an initiation-competent monomeric complex and provides insights into the mechanisms of Pol I-specific initiation and regulation. |
External links | Nat Commun / PubMed:27418309 / PubMed Central |
Methods | EM (single particle) |
Resolution | 4.8 Å |
Structure data | |
Chemicals | ChemComp-ZN: |
Source |
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Keywords | RNA POLYMERASE / TRANSCIPTION |