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-Structure paper
Title | Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. |
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Journal, issue, pages | Leukemia, Vol. 30, Page 2364-2372, Year 2016 |
Publish date | Apr 27, 2016 (structure data deposition date) |
![]() | Hing, Z.A. / Fung, H.Y. / Ranganathan, P. / Mitchell, S. / El-Gamal, D. / Woyach, J.A. / Williams, K. / Goettl, V.M. / Smith, J. / Yu, X. ...Hing, Z.A. / Fung, H.Y. / Ranganathan, P. / Mitchell, S. / El-Gamal, D. / Woyach, J.A. / Williams, K. / Goettl, V.M. / Smith, J. / Yu, X. / Meng, X. / Sun, Q. / Cagatay, T. / Lehman, A.M. / Lucas, D.M. / Baloglu, E. / Shacham, S. / Kauffman, M.G. / Byrd, J.C. / Chook, Y.M. / Garzon, R. / Lapalombella, R. |
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Methods | X-ray diffraction |
Resolution | 2.5 Å |
Structure data | ![]() PDB-5jlj: |
Chemicals | ![]() ChemComp-GNP: ![]() ChemComp-MG: ![]() ChemComp-GOL: ![]() ChemComp-CL: ![]() ChemComp-6L8: ![]() ChemComp-HOH: |
Source |
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![]() | PROTEIN TRANSPORT / HEAT repeat / Exportin-1 / Nuclear Transport / Transport receptor-Inhibitor complex |