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-Structure paper
Title | Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance. |
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Journal, issue, pages | Nat Commun, Vol. 7, Page 11384-11384, Year 2016 |
Publish date | Mar 1, 2016 (structure data deposition date) |
Authors | Brooun, A. / Gajiwala, K.S. / Deng, Y.L. / Liu, W. / Bolanos, B. / Bingham, P. / He, Y.A. / Diehl, W. / Grable, N. / Kung, P.P. ...Brooun, A. / Gajiwala, K.S. / Deng, Y.L. / Liu, W. / Bolanos, B. / Bingham, P. / He, Y.A. / Diehl, W. / Grable, N. / Kung, P.P. / Sutton, S. / Maegley, K.A. / Yu, X. / Stewart, A.E. |
External links | Nat Commun / PubMed:27122193 |
Methods | X-ray diffraction |
Resolution | 2.62 - 2.99 Å |
Structure data | PDB-5ij7: PDB-5ij8: |
Chemicals | ChemComp-6BN: ChemComp-ZN: ChemComp-HOH: |
Source |
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Keywords | transferase/transferase inhibitor / lysine methyltransferase / transferase-transferase inhibitor complex |