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TitleUsing structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase.
Journal, issue, pagesNucleic Acids Res., Vol. 44, Page 4440-4449, Year 2016
Publish dateSep 2, 2015 (structure data deposition date)
AuthorsWang, H.C. / Ho, C.H. / Chou, C.C. / Ko, T.P. / Huang, M.F. / Hsu, K.C. / Wang, A.H.
External linksNucleic Acids Res. / PubMed:26980279
MethodsX-ray diffraction
Resolution2.09 - 2.4 Å
Structure data

PDB-5ayr:
The crystal structure of SAUGI/human UDG complex
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-5ays:
Crystal structure of SAUGI/HSV UDG complex
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • staphylococcus aureus (bacteria)
  • human herpesvirus 1 (strain 17)
KeywordsHYDROLASE INHIBITOR / DNA mimic protein / DNA mimicking / uracil-DNA glycosylase inhibitor / uracil-DNA glycosylase / Herpes simplex virus

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