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TitleThe role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase.
Journal, issue, pagesBiochim. Biophys. Acta, Vol. 1864, Page 655-666, Year 2016
Publish dateNov 18, 2015 (structure data deposition date)
AuthorsValsecchi, W.M. / Cousido-Siah, A. / Defelipe, L.A. / Mitschler, A. / Podjarny, A. / Santos, J. / Delfino, J.M.
External linksBiochim. Biophys. Acta / PubMed:26969784
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-5euc:
The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • trypanosoma cruzi (strain cl brener) (eukaryote)
KeywordsTRANSFERASE / HPRT / phosphoribosyltransferase / T. cruzi / quaternary structure / enzymatic activity modulation / stability / proteolysis / reversible oligomerization / disorder C-terminal region / bisphosphonates

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