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TitleCombinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy.
Journal, issue, pagesBiochem. J., Vol. 473, Page 1329-1341, Year 2016
Publish dateJun 22, 2015 (structure data deposition date)
AuthorsCohen, I. / Kayode, O. / Hockla, A. / Sankaran, B. / Radisky, D.C. / Radisky, E.S. / Papo, N.
External linksBiochem. J. / PubMed:26957636
MethodsX-ray diffraction
Resolution1.83 Å
Structure data

PDB-5c67:
Human Mesotrypsin in complex with amyloid precursor protein inhibitor variant APPI-M17G/I18F/F34V
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHyrdolase/Hydrolase inhibitor / APPI / Kunitz domain / Trypsin / Hyrdolase-Hydrolase inhibitor complex

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