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TitleStructural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
Journal, issue, pagesJ. Org. Chem., Vol. 81, Page 2261-2279, Year 2016
Publish dateAug 17, 2015 (structure data deposition date)
AuthorsKel In, A.V. / Zlatev, I. / Harp, J. / Jayaraman, M. / Bisbe, A. / O Shea, J. / Taneja, N. / Manoharan, R.M. / Khan, S. / Charisse, K. ...Kel In, A.V. / Zlatev, I. / Harp, J. / Jayaraman, M. / Bisbe, A. / O Shea, J. / Taneja, N. / Manoharan, R.M. / Khan, S. / Charisse, K. / Maier, M.A. / Egli, M. / Rajeev, K.G. / Manoharan, M.
External linksJ. Org. Chem. / PubMed:26940174
MethodsX-ray diffraction
Resolution1.2 - 1.993 Å
Structure data

PDB-5d8t:
RNA octamer containing (S)-5' methyl, 2'-F U.
Method: X-RAY DIFFRACTION / Resolution: 1.2 Å

PDB-5dek:
RNA octamer containing dT
Method: X-RAY DIFFRACTION / Resolution: 1.993 Å

PDB-5der:
RNA oligonucleotide containing (R)-C5'-ME-2'F U
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-NCO:
COBALT HEXAMMINE(III)

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
KeywordsRNA / modified base / oligonucleotide

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