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TitleDisordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Journal, issue, pagesScience, Vol. 351, Page 1208-1213, Year 2016
Publish dateDec 10, 2015 (structure data deposition date)
AuthorsMavrakis, K.J. / McDonald, E.R. / Schlabach, M.R. / Billy, E. / Hoffman, G.R. / deWeck, A. / Ruddy, D.A. / Venkatesan, K. / Yu, J. / McAllister, G. ...Mavrakis, K.J. / McDonald, E.R. / Schlabach, M.R. / Billy, E. / Hoffman, G.R. / deWeck, A. / Ruddy, D.A. / Venkatesan, K. / Yu, J. / McAllister, G. / Stump, M. / deBeaumont, R. / Ho, S. / Yue, Y. / Liu, Y. / Yan-Neale, Y. / Yang, G. / Lin, F. / Yin, H. / Gao, H. / Kipp, D.R. / Zhao, S. / McNamara, J.T. / Sprague, E.R. / Zheng, B. / Lin, Y. / Cho, Y.S. / Gu, J. / Crawford, K. / Ciccone, D. / Vitari, A.C. / Lai, A. / Capka, V. / Hurov, K. / Porter, J.A. / Tallarico, J. / Mickanin, C. / Lees, E. / Pagliarini, R. / Keen, N. / Schmelzle, T. / Hofmann, F. / Stegmeier, F. / Sellers, W.R.
External linksScience / PubMed:26912361
MethodsX-ray diffraction
Resolution2.34 Å
Structure data

PDB-5fa5:
Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.34 Å

Chemicals

ChemComp-MTA:
5'-DEOXY-5'-METHYLTHIOADENOSINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/PROTEIN BINDING / Methyl Transferase / TRANSFERASE-PROTEIN BINDING complex

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