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-Structure paper
Title | Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 24, Page 1384-1391, Year 2016 |
Publish date | Jan 4, 2016 (structure data deposition date) |
Authors | Lotesta, S.D. / Marcus, A.P. / Zheng, Y. / Leftheris, K. / Noto, P.B. / Meng, S. / Kandpal, G. / Chen, G. / Zhou, J. / McKeever, B. ...Lotesta, S.D. / Marcus, A.P. / Zheng, Y. / Leftheris, K. / Noto, P.B. / Meng, S. / Kandpal, G. / Chen, G. / Zhou, J. / McKeever, B. / Bukhtiyarov, Y. / Zhao, Y. / Lala, D.S. / Singh, S.B. / McGeehan, G.M. |
External links | Bioorg. Med. Chem. / PubMed:26897089 |
Methods | X-ray diffraction |
Resolution | 2.5 Å |
Structure data | PDB-5hcv: |
Chemicals | ChemComp-60R: ChemComp-CL: ChemComp-HOH: |
Source |
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Keywords | SIGNALING PROTEIN / Mineralocorticoid Receptor / Ligand-binding domain / MR-LBD / Antagonists / co-crystal |