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TitleStructural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers.
Journal, issue, pagesCancer Cell, Vol. 29, Page 173-185, Year 2016
Publish dateFeb 21, 2014 (structure data deposition date)
AuthorsGrandin, M. / Meier, M. / Delcros, J.G. / Nikodemus, D. / Reuten, R. / Patel, T.R. / Goldschneider, D. / Orriss, G. / Krahn, N. / Boussouar, A. ...Grandin, M. / Meier, M. / Delcros, J.G. / Nikodemus, D. / Reuten, R. / Patel, T.R. / Goldschneider, D. / Orriss, G. / Krahn, N. / Boussouar, A. / Abes, R. / Dean, Y. / Neves, D. / Bernet, A. / Depil, S. / Schneiders, F. / Poole, K. / Dante, R. / Koch, M. / Mehlen, P. / Stetefeld, J.
External linksCancer Cell / PubMed:26859457
MethodsX-ray diffraction
Resolution2.64 Å
Structure data

PDB-4ove:
X-ray Crystal Structure of Mouse Netrin-1
Method: X-RAY DIFFRACTION / Resolution: 2.64 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsAPOPTOSIS / similar to laminin gamma-1 / domain VI: beta-sandwich jelly-roll / domains V-1 / V-2 / V-3: laminin-type epidermal growth factor / structural calcium / axon guidance cue / survival factor / neogenin / DCC / UNC5A / UNC5B / UNC5C / UNC5D / DSCAM / extracellular matrix

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