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Structure paper

TitleA Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.
Journal, issue, pagesAcs Chem. Biol., Vol. 11, Page 1058-1065, Year 2016
Publish dateJan 10, 2016 (structure data deposition date)
AuthorsUppalapati, M. / Lee, D.J. / Mandal, K. / Li, H. / Miranda, L.P. / Lowitz, J. / Kenney, J. / Adams, J.J. / Ault-Riche, D. / Kent, S.B. / Sidhu, S.S.
External linksAcs Chem. Biol. / PubMed:26745345
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-5hhc:
Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21/n
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-5hhd:
Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsDE NOVO PROTEIN / HETEROCHIRAL PROTEIN-PROTEIN COMPLEX / D-PROTEIN ANTAGONIST / GROWTH FACTOR-INHIBITOR COMPLEX / RACEMIC PROTEIN CRYSTALLOGRAPHY / RACEMIC CRYSTALLOGRAPHY

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