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TitleA Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
Journal, issue, pagesJ. Mol. Biol., Vol. 428, Page 1023-1040, Year 2016
Publish dateSep 29, 2015 (structure data deposition date)
AuthorsDuffy, C.M. / Hilbert, B.J. / Kelch, B.A.
External linksJ. Mol. Biol. / PubMed:26688547
MethodsX-ray diffraction
Resolution1.93 - 2.6653 Å
Structure data

PDB-5e0t:
Human PCNA mutant - S228I
Method: X-RAY DIFFRACTION / Resolution: 2.6653 Å

PDB-5e0u:
Human PCNA variant (S228I) complexed with p21 at 1.9 Angstroms
Method: X-RAY DIFFRACTION / Resolution: 1.93 Å

PDB-5e0v:
Human PCNA variant (S228I) complexed with FEN1 at 2.1 Angstroms
Method: X-RAY DIFFRACTION / Resolution: 2.074 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / DNA replication / sliding clamp

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