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TitleStructure of the voltage-gated calcium channel Cav1.1 complex.
Journal, issue, pagesScience, Vol. 350, Issue 6267, Page aad2395, Year 2015
Publish dateDec 18, 2015
AuthorsJianping Wu / Zhen Yan / Zhangqiang Li / Chuangye Yan / Shan Lu / Mengqiu Dong / Nieng Yan /
PubMed AbstractThe voltage-gated calcium channel Ca(v)1.1 is engaged in the excitation-contraction coupling of skeletal muscles. The Ca(v)1.1 complex consists of the pore-forming subunit α1 and auxiliary subunits ...The voltage-gated calcium channel Ca(v)1.1 is engaged in the excitation-contraction coupling of skeletal muscles. The Ca(v)1.1 complex consists of the pore-forming subunit α1 and auxiliary subunits α2δ, β, and γ. We report the structure of the rabbit Ca(v)1.1 complex determined by single-particle cryo-electron microscopy. The four homologous repeats of the α1 subunit are arranged clockwise in the extracellular view. The γ subunit, whose structure resembles claudins, interacts with the voltage-sensing domain of repeat IV (VSD(IV)), whereas the cytosolic β subunit is located adjacent to VSD(II) of α1. The α2 subunit interacts with the extracellular loops of repeats I to III through its VWA and Cache1 domains. The structure reveals the architecture of a prototypical eukaryotic Ca(v) channel and provides a framework for understanding the function and disease mechanisms of Ca(v) and Na(v) channels.
External linksScience / PubMed:26680202
MethodsEM (single particle)
Resolution4.2 - 6.1 Å
Structure data

6475

3jbr

EMDB-6475: Cryo-EM structure of the rabbit voltage-gated calcium channel Cav1.1 at 4.2 angstrom resolution
PDB-3jbr: Cryo-EM structure of the rabbit voltage-gated calcium channel Cav1.1 complex at 4.2 angstrom
Method: EM (single particle) / Resolution: 4.2 Å

6476

3jbr

EMDB-6476: Cryo-EM structure of the rabbit voltage-gated calcium channel Cav1.1 at 6.1 angstrom resolution
PDB-3jbr: Cryo-EM structure of the rabbit voltage-gated calcium channel Cav1.1 complex at 4.2 angstrom
Method: EM (single particle) / Resolution: 6.1 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

ChemComp-BMA:
beta-D-mannopyranose / Mannose

Source
  • oryctolagus cuniculus (rabbit)
  • rattus norvegicus (Norway rat)
KeywordsMEMBRANE PROTEIN / voltage-gated calcium channel

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