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TitleWhat a Difference an OH Makes: Conformational Dynamics as the Basis for the Ligand Specificity of the Neomycin-Sensing Riboswitch.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 55, Page 1527-1530, Year 2016
Publish dateJan 14, 2015 (structure data deposition date)
AuthorsDuchardt-Ferner, E. / Gottstein-Schmidtke, S.R. / Weigand, J.E. / Ohlenschlager, O. / Wurm, J.P. / Hammann, C. / Suess, B. / Wohnert, J.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:26661511
MethodsNMR (solution)
Structure data

PDB-2mxs:
Solution NMR-structure of the neomycin sensing riboswitch RNA bound to paromomycin
Method: SOLUTION NMR

PDB-2n0j:
Solution NMR Structure of the 27 nucleotide engineered neomycin sensing riboswitch RNA-ribostamycin complex
Method: SOLUTION NMR

Chemicals

ChemComp-PAR:
PAROMOMYCIN / Antimicrobial, medication*YM

ChemComp-RIO:
RIBOSTAMYCIN / antibiotic*YM

Source
  • synthetic construct (others)
KeywordsRNA / Riboswitch / Aminoglycoside / Riboswitches / RNA-ligand interaction / Aminoglycosides / RNA recognition / RNA structure

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