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TitleCSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors.
Journal, issue, pagesMabs, Vol. 8, Page 436-453, Year 2016
Publish dateSep 23, 2015 (structure data deposition date)
AuthorsPanousis, C. / Dhagat, U. / Edwards, K.M. / Rayzman, V. / Hardy, M.P. / Braley, H. / Gauvreau, G.M. / Hercus, T.R. / Smith, S. / Sehmi, R. ...Panousis, C. / Dhagat, U. / Edwards, K.M. / Rayzman, V. / Hardy, M.P. / Braley, H. / Gauvreau, G.M. / Hercus, T.R. / Smith, S. / Sehmi, R. / McMillan, L. / Dottore, M. / McClure, B.J. / Fabri, L.J. / Vairo, G. / Lopez, A.F. / Parker, M.W. / Nash, A.D. / Wilson, N.J. / Wilson, M.J. / Owczarek, C.M.
External linksMabs / PubMed:26651396
MethodsX-ray diffraction
Resolution3.97 Å
Structure data

PDB-5dwu:
Beta common receptor in complex with a Fab
Method: X-RAY DIFFRACTION / Resolution: 3.97 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Fab complex / antigen recognition / therapeutic antibody

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