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TitleGuanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases.
Journal, issue, pagesNat Commun, Vol. 6, Page 8923-8923, Year 2015
Publish dateMar 26, 2015 (structure data deposition date)
AuthorsBuey, R.M. / Ledesma-Amaro, R. / Velazquez-Campoy, A. / Balsera, M. / Chagoyen, M. / de Pereda, J.M. / Revuelta, J.L.
External linksNat Commun / PubMed:26558346
MethodsX-ray diffraction
Resolution1.25 - 2.25 Å
Structure data

PDB-4z0g:
Structure of the IMPDH from Ashbya gossypii bound to GMP
Method: X-RAY DIFFRACTION / Resolution: 1.25 Å

PDB-4z87:
Structure of the IMP dehydrogenase from Ashbya gossypii bound to GDP
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-5GP:
GUANOSINE-5'-MONOPHOSPHATE

ChemComp-K:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-ACT:
ACETATE ION

Source
  • ashbya gossypii (strain atcc 10895 / cbs 109.51 / fgsc 9923 / nrrl y-1056) (fungus)
  • ashbya gossypii (strain atcc 10895) (fungus)
KeywordsOXIDOREDUCTASE / IMP dehydrgoenase / Bateman domain

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