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Structure paper

TitleDNA-dependent formation of transcription factor pairs alters their binding specificity.
Journal, issue, pagesNature, Vol. 527, Page 384-388, Year 2015
Publish dateJan 21, 2015 (structure data deposition date)
AuthorsJolma, A. / Yin, Y. / Nitta, K.R. / Dave, K. / Popov, A. / Taipale, M. / Enge, M. / Kivioja, T. / Morgunova, E. / Taipale, J.
External linksNature / PubMed:26550823
MethodsX-ray diffraction
Resolution1.6 - 3.5 Å
Structure data

PDB-4xrm:
homodimer of TALE type homeobox transcription factor MEIS1 complexes with specific DNA
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-4xrs:
Heterodimeric complex of transcription factors MEIS1 and DLX3 on specific DNA
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

PDB-5bng:
monomer of TALE type homeobox transcription factor MEIS1 complexes with specific DNA
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSCRIPTION / TALE homeobox / MEIS / Complex / DNA / heterodimer / PROTEIN/DNA / Protein-DNA complex / transcription factor / TALE type homeobox protein

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